منابع مشابه
High SINE RNA Expression Correlates with Post-Transcriptional Downregulation of BRCA1
Short Interspersed Nuclear Elements (SINEs) are non-autonomous retrotransposons that comprise a large fraction of the human genome. SINEs are demethylated in human disease, but whether SINEs become transcriptionally induced and how the resulting transcripts may affect the expression of protein coding genes is unknown. Here, we show that downregulation of the mRNA of the tumor suppressor gene BR...
متن کاملDownregulation of BRCA1-BRCA2-containing complex subunit 3 sensitizes glioma cells to temozolomide
We previously found that BRCA1-BRCA2-containing complex subunit 3 (BRCC3) was highly expressed in tumorigenic rat glioma cells. However, the functional role of BRCC3 in human glioma cells remains to be characterized. This study indicated that the upregulation of BRCC3 expression was induced in two human malignant glioblastoma U251 and A172 cell lines following exposure to the alkylating agent, ...
متن کاملmiR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors.
Expression of BRCA1 is commonly decreased in sporadic breast tumors, and this correlates with poor prognosis of breast cancer patients. Here we show that BRCA1 transcripts are selectively enriched in the Argonaute/miR-182 complex and miR-182 downregulates BRCA1 expression. Antagonizing miR-182 enhances BRCA1 protein levels and protects them from IR-induced cell death, while overexpressing miR-1...
متن کاملBRCA1 A-Complex fine tunes repair functions of BRCA1
mutations in BRCA1 increase the risk of breast and ovarian cancer, but the specific pathways driving breast and ovarian cancer development in BRCA1 mutants are currently unclear [1]. Several studies have demonstrated that BRCA1 is required for cellular responses to DNA double strand breaks (DSBs) and homologous recombination (HR), although its exact role in these processes is unclear. BRCA1 con...
متن کاملBRCA1 testing
Mutations in BRCA1 confer a high lifetime risk for both breast and ovarian cancer. Many different BRCA1 mutations have been described in families with earlyonset breast and ovarian cancer [1, 2]. The presence of recurrent mutations in BRCA1 suggests the presence of founder effects. BRCA1 “de novo” mutations are very rare. 66 families were studied in Szczecin with strong aggregations of breast/o...
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ژورنال
عنوان ژورنال: Breast Cancer Research
سال: 1999
ISSN: 1465-542X
DOI: 10.1186/bcr-1999-66638